间变性大细胞淋巴瘤的形态学及免疫表型与诊断预后的相关性

顾安康 孙蕾娜 战忠利

顾安康, 孙蕾娜, 战忠利. 间变性大细胞淋巴瘤的形态学及免疫表型与诊断预后的相关性[J]. 中国肿瘤临床, 2008, 35(15): 841-844. doi:
引用本文: 顾安康, 孙蕾娜, 战忠利. 间变性大细胞淋巴瘤的形态学及免疫表型与诊断预后的相关性[J]. 中国肿瘤临床, 2008, 35(15): 841-844. doi:
GU Ankang, SUN Leina, ZHAN Zhongli. Anaplastic Large Cell Lymphoma: Correlation of Clinicopathologic Features with Diagnosis and Prognosis[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2008, 35(15): 841-844. doi:
Citation: GU Ankang, SUN Leina, ZHAN Zhongli. Anaplastic Large Cell Lymphoma: Correlation of Clinicopathologic Features with Diagnosis and Prognosis[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2008, 35(15): 841-844. doi:

间变性大细胞淋巴瘤的形态学及免疫表型与诊断预后的相关性

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详细信息
  • 中图分类号: R733.1

Anaplastic Large Cell Lymphoma: Correlation of Clinicopathologic Features with Diagnosis and Prognosis

  • 摘要: 目的 :研究间变性大细胞淋巴瘤(ALCL)的临床病理特点和免疫表型,提高该疾病的早期诊断,并比较ALK+与ALK-在临床表现、治疗和预后的不同点。 方法 :对原诊断为ALCL的20例病例重新行组织学观察和免疫组织化学染色(ABC法)并复习相关文献。 结果 :20例中15例属于T/Null细胞表型,结合免疫组化诊断为ALCL,15例ALCL均强烈表达CD30;ALK阳性者9例,ALK的表达与患者性别,免疫分型、组织分型、临床分期无相关性;而与患者年龄及化疗敏感性具有相关性(P<0.05)。其余5例为B细胞表型(CD20强阳性),结合新的淋巴瘤分类标准,被诊断为弥漫性大B细胞淋巴瘤(DLBCL)。 结论 :间变性大细胞淋巴瘤中具有标志性的大细胞出现CD30、ALK和EMA阳性时,对ALCL的诊断具有重要价值;ALK+ALCL与ALK-ALCL在遗传特征,临床表现及治疗预后的不同,使其作为一种新的病理类型被提出具有合理性。

     

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出版历程
  • 收稿日期:  2008-03-24
  • 修回日期:  2008-05-21
  • 刊出日期:  2008-08-15

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