造血干细胞移植在神经母细胞瘤治疗中的应用

朱佳; 张翼鷟

doi:10.12354/j.issn.1000-8179.2023.20221553

造血干细胞移植在神经母细胞瘤治疗中的应用

doi: 10.12354/j.issn.1000-8179.2023.20221553

朱佳^{1, 2,},
张翼鷟^{1, 2, ,}

1.
肿瘤医学协同创新中心，华南恶性肿瘤防治全国重点实验室（广州市510060）
2.
中山大学肿瘤防治中心儿童肿瘤科

基金项目: 本文课题受国家重点研发计划项目（编号：2022YFC2705005）资助

详细信息

作者简介:
朱佳：专业方向为儿童肿瘤的化疗和靶向治疗

通讯作者:
张翼鷟　zhangyzh@sysucc.org.cn

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- 文章访问数: 120
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- PDF下载量: 37
- 被引次数: 0
出版历程
- 收稿日期: 2022-11-03
- 录用日期: 2023-01-05
- 修回日期: 2023-01-04

Application of hematopoietic stem cell transplantation in the treatment of neuroblastoma

Jia Zhu^{1, 2
,},
Yizhuo Zhang^{1, 2
, ,}

1.
Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Guangzhou 510060, China
2.
Department of Pediatric Oncology, Sun Yat-sen University Cancer Center, Guangzhou 510060, China

Funds: This work was supported by the National Key Research and Development Plan (No. 2022YFC2705005)

More Information

Corresponding author: Yizhuo Zhang; E-mail: zhangyzh@sysucc.org.cn

摘要

摘要: 高危神经母细胞瘤（neuroblastoma，NB）恶性程度高且预后差，需要综合治疗。造血干细胞移植（hematopoietic stem cell transplantation，HSCT）是诱导缓解后巩固治疗中的重要组成部分，目前以自体造血干细胞移植（autologous HSCT，AHSCT）为主，取得较好的客观缓解，也有复发/难治性患儿接受异基因造血干细胞移植（allogeneic HSCT，allo-HSCT）。作为超大剂量化疗下的支持治疗，双次HSCT比单次HSCT更能改善患儿无事件生存。HSCT预处理方案以白消安/马法兰（Bu/Mel）和卡铂/依托泊苷/马法兰（CEM）为主。Bu/Mel在无事件生存率上优于CEM方案。尽管免疫治疗明显改善了高危患儿的生存期，但是HSCT目前仍在一线综合治疗中处于重要地位。本文拟就HSCT在NB中的应用进行综述。
- 神经母细胞瘤 /
- 高危 /
- 造血干细胞移植 /
- 预处理方案
Abstract: High-risk neuroblastoma (HRNBL) is an aggressive solid tumor with a poor prognosis. Treatment is based on multidisciplinary collaboration. Hematopoietic stem cell transplantation (HSCT) plays an important role in the consolidation phase. Autologous stem cell transplantation is frequently used in clinical practice. Some relapsed/refractory patients achieve a good response through the use of allogeneic HSCT (allo-HSCT). Tandem transplantation results in a significantly better event-free survival (EFS) than single transplantation. Conditioning regimens include busulfan/melphalan (Bu/Mel) and carboplatin/etoposide/melphalan (CEM) for advanced-stage neuroblastoma. Bu/Mel is associated with better EFS than CEM. HSCT is the standard of care in the treatment of HRNBL, although immunotherapy has significantly improved survival. This article reviews the use of HSCT in neuroblastoma.
- neuroblastoma (NB) /
- high-risk /
- hematopoietic stem cell transplantation (HSCT) /
- conditioning regimen

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参考文献(31)

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