Abstract:
Objective To investigate the effects of different surgical approaches on the efficacy and safety of patients with primary central nervous system lymphoma (PCNSL).
Methods The clinical data of 130 PCNSL patients admitted to The First Affiliated Hospital of University of Science and Tecnology of China between July 2012 and May 2023 were retrospectively analyzed. Patients were assigned into resection and biopsy groups according to the surgical approach. The safety and efficacy of the two groups were compared, including the objective response rate (ORR), overall survival (OS), and progression-free survival (PFS) after chemotherapy.
Results ORR and 2-year OS and PFS rates of the resection group were not significantly different from those of the biopsy group (ORR: 63.2% vs. 62.8%; 2-year OS rate: 68.6% vs. 73.7%; 2-year PFS rate: 35.2% vs. 40.7%, all P>0.05). The incidence of postoperative complications was significantly higher in the resection group than in the biopsy group (29.3% vs. 11.4%, P=0.04). The difference in the length of hospitalization between the two groups was not statistically significant. Treatment of the biopsy group was less expensive (P<0.01).
Conclusions In patients with PCNSL, biopsy and resection had comparable efficacy; however, the safety profile was better, and hospitalization was less costly in biopsy than in resection.
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