Abstract: Neuroblastoma (NB) is a common malignant solid tumor that occurs during childhood; it has a significant heterogeneity in clinical symptoms and outcome. NB diagnosis is complicated, and various clinical techniques are often involved in examining imagery, cellular morphology, immunohistochemical staining, gene and molecule biology, and operation excision scope. Diagnoses are graded based on danger extent, which is indicated by clinical stages and unfavorable prognosis factors. These characteristics are the basis for formulating the corresponding synthetic treatment plan. Limited studies are available on treatment norms for adult cases of NB; such cases are currently diagnosed and treated in accordance with child NB diagnosis and treatment norms. An adult patient diagnosed with NB stage 4 is presented. This patient experienced obvious relief from the symptoms after whole body chemotherapy, with further surgery operation indications. This successful case of multi-disciplinary joint diagnosis and cooperative treatment may provide potential treatment techniques for similar patients.