Abstract: Lung cancer can be cured surgically in its early stages. However, the recurrence rate remains high after surgical treatment of lung cancer. Spread through air spaces (STAS) is a new form of invasion of lung adenocarcinoma described by the World Health Organization in 2015 and is used as the standard for the exclusion of minimally invasive adenocarcinoma. An increasing number of studies have shown that STAS as a method of lung cancer invasion is significantly related to poor prognosis of lung cancer patients after surgery and can be used as a prognostic predictor of lung adenocarcinoma in the early stages after surgery. Looking for STAS in postoperative specimens following surgery for lung cancer is clinically feasible, can be applied to clinical practice, and can help to optimize the treatment plan for lung cancer. This article reviews the research regarding the prognosis of lung cancer patients presenting with STAS and explores the clinical significance of STAS-positive status for optimizing lung cancer treatment.