Abstract: Objective : To evaluate the relationship between acoustic schwannoma and GGF,Ki67,to further explore the molecular mechanism of acoustic schwannoma. Methods : GGF,Ki67 immunohistochemistry were used to retrospectively analyse proliferarive activity in 49 acoustic schwannomas. And cell were cultured with GGF. The relationship between proliforation,growth rate and GGF,Ki67 expression was evaluated using rank correlation and Chi-square test. Results : There was significant association between GGF,Ki67 expression and growth rate in acoustic schwannomas,and is a correlation between GGF and Ki67. The higher in GG,Ki67 expression,the more rapid is the tumor growth. GGF remarkably promotes schwannoma cell to grow like tumor. Conclusions : GGF may partly result in abnormal hyperplasia of acoustic schwannoma,There was positive correlation between the expression of GGF,Ki67 and acoustic schwannoma growth rate. Ki67 antigen may suggest proliferation of acoustic schwannoma. GGF with Ki67 antigen can evaluate growth trend of postoperative acoustic schwannoma.