Abstract: Objective :To evaluate efficacy and toxic reactions of nedaplatin plus 5-fluorouracil in treatment of advanced squamous-cell carcinoma of esophagus. Methods :A total of 24 patients with advanced squamous-cell carcinoma of esophagus were selected and nedaplatin was administered at a dose of 80~100mg/m²,with 500ml of saline by drip infusion for 2 hours on day 1,and 5-fluorouracil at a dose of 1.0g/day intravenously over 4 hours on day 1 to 5. Chemotherapy was repeatedly given every 28 days and the efficacy was evaluated after 2 cycles of administration. Results :Response and toxicity could be assessed in all the 24 patients.The overall response rate was 41.7%.In 14 patients who didn't receive chemotherapy previously,the response rate was 50.0% with a complete response in 1 cases and partial response in 6.In 10 patients previously treated with cisplatin and 5-fluorouracil,the response rate was 30.0% with 3 partial cases.The median survival time and one-year survival rate was 9.4 months and 25.0%,respectively.The major toxicity was myelosuppression,in which grade Ⅲ thrombocytopenia was observed in 4 patients(16.7%)and grade Ⅲ~Ⅳ neutropenia in 3 patients(12.5%).Gastrointestinal toxicity was mild and renal or hepatic toxicity was not observed. Conclusion :The combined chemotherapy with nedaplatin and 5-fluorouracil can be considered as a first regimen in the treatment of advanced squamous-cell carcinoma of esophagus,in which nedaplatin may be a substitute of cisplatin,not only for the patients without having chemotherapy previously,but also for those resistant to cisplatin.This regimen is active and well tolerated,especially to the aged patients.