Abstract: The standard therapy of nasopharyngeal carcinoma is radiation therapy,but the symptoms for more than 60% of patients are of local advanced or advanced stage.Local metastasis and distance after single radiotherapy are high.Nasopharyngeal carcinoma is also a chemotherapy-sensitive tumor and radiation therapy in combination with chemotherapy can significantly improve the efficacy of the local advanced nasopharyngeal carcinoma.Research in the past few years can indicated,too,that the mode of treatment with synchronous radio-chemotherapy does benefit to the improvement of total survivals and tumor-free survival,whereas the roles of adjuvant chemotherapy before and after radiotherapy is not clear yet.This study summarized the current situation and progression in radiotherapy plus chemotherapy on local advanced nasopharyngeal carcinoma.