钙-基因与结直肠腺瘤发病风险关联的研究进展

赖小练; 黄立敏; 景楚滢; 鲁朔焱; 李丹; 王慧敏; 李勇

doi:10.12354/j.issn.1000-8179.2021.20210199

钙-基因与结直肠腺瘤发病风险关联的研究进展

doi: 10.12354/j.issn.1000-8179.2021.20210199

1.
贵州大学医学院（贵阳市550025）
2.
贵州省人民医院肿瘤科, 贵州省癌症中心
3.
松桃县人民医院消化肿瘤科

基金项目: 本文课题受国家自然科学基金项目（编号：81960587）和贵州省科技计划项目（编号：黔科合支撑[2021]一般067）资助。

详细信息

作者简介:
赖小练：专业方向为钙重吸收基因及钙摄入水平与贵州黔南地区结直肠腺瘤的相关性研究

通讯作者:
李勇　liyong7229771@163.com

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出版历程
- 收稿日期: 2021-01-19

Research progress on the association between calcium–gene interactions and the risk of colorectal adenoma

1.
Guizhou University, Medical College, Guiyang 550025, China
2.
Department of Oncology, Guizhou Provincial People’s Hospital, Guizhou Cancer Center, Guiyang 550002, China
3.
Department of Gastroenterology, Songtao County People's Hospital, Tongren 554100, China

Funds: This work was supported by the National Natural Science Foundation of China (No. 81960587) and the Guizhou Science and Technology Project (No. Qiankehe Support [2021] General 067).

More Information

Corresponding author: Yong Li; E-mail: liyong7229771@163.com

摘要

摘要: 结直肠癌是胃肠道中常见的恶性肿瘤，近几年，结直肠癌的发病率和死亡率保持着上升趋势，居高不下。而结直肠腺瘤是结直肠癌最重要的癌前病变，其发病机制对于结直肠癌早期诊疗至关重要。结直肠腺瘤的发病机制较为复杂，一般涉及多个基因的相互作用和信号通路。且钙剂与结直肠腺瘤的关联研究在近年来也引起广泛关注。因此，本文对钙与基因的相互作用和结直肠腺瘤发病风险的关系进行综述，为结直肠癌的早期筛查、诊断和早期治疗提供参考。
- 结直肠腺瘤 /
- 基因 /
- 钙 /
- 化学预防
Abstract: Colorectal cancer is a common malignancy in gastrointestinal tract. In recent years, the incidence and mortality rates of colorectal cancer have maintained an upward trend and remain high. Colorectal adenoma is the most prominent precancerous lesion associated with colorectal cancer, and its pathogenesis is very important for the early diagnosis and treatment of colorectal cancer. The pathogenesis of colorectal adenoma is complicated, generally involving interactions among multiple genes and signaling pathways. Studies of associations between calcium and colorectal adenoma have attracted widespread attention in recent years. This review summarizes the relationships between calcium and gene interactions and the risk of colorectal adenoma, providing references for the early screening, diagnosis, and early treatment of colorectal cancer.
- colorectal adenoma /
- gene /
- calcium /
- chemoprevention

HTML全文

图 1 结直肠癌发生分子基础^[15]

下载: 全尺寸图片幻灯片

表 1 结直肠肿瘤风险的分子表型生物标志物^[15]

序号	种类	生物标志物表达
1	结肠癌发生途径
	APC途径	APC, E-cadherin
	MMR途径	MSH2、MLH1、TGFβ RⅡ、bax
2	细胞周期
	细胞增殖
	短期	Mib-1（Ki-67）
	长期	hTERT
	细胞分化	p21
	细胞凋亡
	抑制	bcl-2
	促进	bax
3	细胞黏附	E-cadherin
4	炎症	COX-2、CRP、 IL-6、 IL-1β、 IL-8、 IL-10、 TNFα
5	氧化平衡	8-OH-dG
6	维生素D/钙代谢	CaSR、VDR、 CYP27B1、CYP24
7	生长因子信号	TGFα、 TGFβ₁、 IGF-Ⅰ、 IGFBP3

下载: 导出CSV

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