杜文, 王晓青, 成娟, 赵丽. 靶向BCMA CAR-T细胞在复发难治性多发性骨髓瘤中的治疗进展[J]. 中国肿瘤临床, 2021, 48(16): 858-862. DOI: 10.12354/j.issn.1000-8179.2021.20210468
引用本文: 杜文, 王晓青, 成娟, 赵丽. 靶向BCMA CAR-T细胞在复发难治性多发性骨髓瘤中的治疗进展[J]. 中国肿瘤临床, 2021, 48(16): 858-862. DOI: 10.12354/j.issn.1000-8179.2021.20210468
Wen Du, Xiaoqing Wang, Juan Cheng, Li Zhao. Progress in anti-BCMA CAR-T therapy for relapsed/refractory multiple myeloma[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2021, 48(16): 858-862. DOI: 10.12354/j.issn.1000-8179.2021.20210468
Citation: Wen Du, Xiaoqing Wang, Juan Cheng, Li Zhao. Progress in anti-BCMA CAR-T therapy for relapsed/refractory multiple myeloma[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2021, 48(16): 858-862. DOI: 10.12354/j.issn.1000-8179.2021.20210468

靶向BCMA CAR-T细胞在复发难治性多发性骨髓瘤中的治疗进展

Progress in anti-BCMA CAR-T therapy for relapsed/refractory multiple myeloma

  • 摘要: 多发性骨髓瘤(multiple myeloma,MM)是由骨髓中浆细胞恶性增殖引起的血液系统恶性肿瘤,现临床上多采取化疗、自体干细胞移植、蛋白酶体抑制剂、免疫调节药物及单克隆抗体等方法治疗,但终将复发不可治愈。复发难治性多发性骨髓瘤(relapsed/refractory multiple myeloma,R/R MM)现仍是治疗中的难题。近年来,随着嵌合抗原受体T细胞(chimeric antigen receptor T cell,CAR-T)技术的发展,靶向BCMA CAR-T治疗作为一种新型的治疗R/R MM的方法,在临床试验中获得了较高的反应率和疗效。本文将对现有的靶向BCMA CAR-T产品的最新研究进行综述。

     

    Abstract: Multiple myeloma (MM) is a hematologic malignancy caused by the malignant proliferation of plasma cells in bone marrow. Currently, chemotherapy, autologous stem cell transplantation, proteasome inhibitors, immunoregulatory drugs, and monoclonal antibodies are used to treat MM in clinical practice, but MM eventually relapses and becomes incurable. The treatment of relapsed/refractory MM (R/R MM) continues to be a difficult challenge. In recent years, with the development of the chimeric antigen receptor T cell (CAR-T) technology, anti-BCMA CAR-T therapy has shown a high response rate and high efficacy in clinical trials as a novel method for the treatment of R/R MM. Herein, we summarize the latest experimental results and prospects of the existing anti-BCMA CAR-T products.

     

/

返回文章
返回