Abstract:
Objective To analyze the clinicopathological characteristics of supratentorial intracerebral schwannomas.
Methods A total of 7 cases diagnosed as supratentorial intracerebral schwannomas from November 2011 to May 2019, at Xuanwu Hospital Capital, Capital Medical University were collected and retrospectively summarized for assessment. The imaging characteristics, pathology, and immunohistochemical characteristics were analyzed, and the relevant literature was reviewed.
Results Among the 7 patients, 3 were women and 4 were men. The average age was 30.6 (8-74) years. Imaging and intraoperative findings suggested that the lesions were mainly located in the brain parenchyma, predominantly in the unilateral brain lobe, with 2 cases with lesions located in the ventricle and involving the brain parenchyma. Computed tomography (CT) and magnetic resonance imaging (MRI) can reveal both cystic and solid masses; MRI showed heterogenous enhancement. Histopathology showed that all 7 cases displayed typical features of schwannoma, with Antoni A and Antoni B areas. 4 cases were accompanied by hemorrhage, cystic degeneration, and calcification. In addition, 2 cases also showed focal necrosis. S-100, SOX-10, and Vimentin were expressed in all 7 cases (100%, 7/7), while GFAP and EMA were each expressed in one case. The proliferation index of Ki-67 was between 3%-10%. None of the patients received chemotherapy or radiotherapy after the operation. To date, no tumor recurrence has been noted, although 2 cases were lost to follow-up.
Conclusions The prognosis of supratentorial intracerebral schwannomas is good, but it is difficult to diagnose accurately before operation. Pathological analysis is of great significance in the diagnosis of supratentorial intracerebral schwannomas. However, further study is needed on the mechanisms of occurrence and development of schwannoma in supratentorial intracerebral schwannomas.
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