何婷婷, 张瑞涛, 史惠蓉, 曹媛, 冯巍, 王文文, 张微微. 卵巢上皮性癌组织中长链非编码RNA PURPL的表达及其意义[J]. 中国肿瘤临床, 2021, 48(19): 979-982. DOI: 10.12354/j.issn.1000-8179.2021.20210961
引用本文: 何婷婷, 张瑞涛, 史惠蓉, 曹媛, 冯巍, 王文文, 张微微. 卵巢上皮性癌组织中长链非编码RNA PURPL的表达及其意义[J]. 中国肿瘤临床, 2021, 48(19): 979-982. DOI: 10.12354/j.issn.1000-8179.2021.20210961
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Tingting He, Ruitao Zhang, Huirong Shi, Yuan Cao, Wei Feng, Wenwen Wang, Weiwei Zhang. Expression and significance of long non-coding RNA PURPL in epithelial ovarian cancer tissues[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2021, 48(19): 979-982. DOI: 10.12354/j.issn.1000-8179.2021.20210961
Citation: Tingting He, Ruitao Zhang, Huirong Shi, Yuan Cao, Wei Feng, Wenwen Wang, Weiwei Zhang. Expression and significance of long non-coding RNA PURPL in epithelial ovarian cancer tissues[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2021, 48(19): 979-982. DOI: 10.12354/j.issn.1000-8179.2021.20210961
shu

卵巢上皮性癌组织中长链非编码RNA PURPL的表达及其意义

Expression and significance of long non-coding RNA PURPL in epithelial ovarian cancer tissues

    摘要
  • 摘要:
      目的  检测长链非编码RNA PURPL（p53 upregulated regulator of p53 levels）在卵巢上皮性癌（epithelial ovarian cancer，EOC）组织中的表达情况，探讨其在卵巢癌发生发展中的作用。
      方法  选用开放医学数据库lncRNASNP2、GEPIA和Kaplan-Meier Plotter检索PURPL在EOC组织中的表达及其与预后的关系。收集2012年10月至2015年10月郑州大学第一附属医院105例患者的临床病理资料，其中包括正常卵巢组织20例、良性卵巢上皮性肿瘤组织20例、EOC组织65例，采用实时荧光定量PCR检测上述不同卵巢组织中的PURPL表达情况，分析EOC组织中PURPL表达与EOC临床病理指标的关系，Kaplan-Meier法分析PURPL表达对EOC患者生存的影响。
      结果  数据库检索显示，EOC组织中PURPL的表达显著高于正常卵巢组织，PURPL表达升高与EOC患者的总生存（overall survival，OS）率和无复发生存期（recurrence-free survival，RFS）缩短相关。实时荧光定量PCR检测显示，晚期EOC组织中的PURPL表达为0.530±0.004，显著高于正常卵巢组织的0.029±0.001、良性卵巢上皮性肿瘤组织的0.135±0.001和早期EOC组织的0.488±0.006的表达（P<0.0001）。临床分期越晚（χ2=10.785，P=0.001）、有淋巴结转移（χ2=4.481，P=0.034）的EOC组织中的PURPL高表达。PURPL表达水平相对较高的EOC患者的OS和RFS，明显短于PURPL表达水平相对较低的患者（P<0.05）。
      结论  PURPL高表达提示EOC患者预后不良，可作为EOC预后监测的潜在标记物。

     

    Abstract:
      Objective  To detect the expression of long non-coding (lnc) RNA PURPL in epithelial ovarian cancer (EOC) tissues and investigate its significance in the progression of ovarian cancer.
      Methods  The lncRNASNP2, GEPIA, and Kaplan–Meier Plotter, which are publicly available databases, were used to explore the expression of PURPL in EOC and its relationship with the prognosis of EOC. The expression of PURPL in 105 samples of different ovarian tissues was detected using real-time PCR, and its correlations to the clinicopathological characteristics of EOC were analyzed. The 105 samples included 20 normal ovarian tissue, 20 benign epithelial ovarian tumor, and 65 EOC tissue samples. They were collected at The First Affiliated Hospital of Zhengzhou University between October 2012 and October 2015. The relationship between the expression of PURPL and the survival of EOC patients was measured using Kaplan–Meier analysis.
      Results  The expression of PURPL in EOC tissues was higher than that in normal ovarian tissues. The upregulated expression of PURPL was related to worse overall survival (OS) and recurrence-free survival (RFS). Real-time PCR revealed that PURPL expression in advanced EOC tissues (0.530±0.004) was higher than that in normal ovarian tissues (0.029±0.001), benign ovarian tumors (0.135±0.001), and early EOC tissues (0.488±0.006) (P<0.0001). Higher expression of PURPL in EOC samples was associated with a more advanced FIGO stage (χ2=10.785, P=0.001) and lymph node metastasis (χ2=4.481, P=0.034). The OS and RFS of patients with EOC with higher expression of PURPL were significantly shorter than those with lower expression of PURPL (P<0.05).
      Conclusions  Upregulation of PURPL indicated poor prognosis of patients with EOC and could be a candidate biomarker for the prognosis of EOC.

     

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