RNA m<sup>5</sup>C甲基化修饰在肿瘤中的研究进展

张安琪; 安萌; 姜博; 唐文强; 潘丽; 付波

doi:10.12354/j.issn.1000-8179.2021.20210966

RNA m⁵C甲基化修饰在肿瘤中的研究进展

doi: 10.12354/j.issn.1000-8179.2021.20210966

张安琪^1,,
安萌²,
姜博¹,
唐文强¹,
潘丽¹,
付波^1, ,

1.
山东第一医科大学附属聊城医院，聊城市人民医院中心实验室（山东省聊城市252000）
2.
检验科

基金项目: 本文课题受国家自然科学基金项目（编号：81702884）资助

详细信息

作者简介:
张安琪：专业方向为肿瘤分子诊断和基础转化研究

通讯作者:
付波　fubo.22@163.com

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- 被引次数: 0
出版历程
- 收稿日期: 2021-06-22
- 网络出版日期: 2021-10-14

Research progress on post-translational RNA 5-methylcytosine methylation in tumors

Anqi Zhang^1
,,
Meng An²,
Bo Jiang¹,
Wenqiang Tang¹,
Li Pan¹,
Bo Fu^{1
, ,}

1.
Department of Central Laboratory,
2.
Department of Clinical Laboratory, Liaocheng People’s Hospital, Liaocheng People’s Hospital Affiliated to Shandong First Medical University, Liaocheng 252000, China

Funds: This work was supported by the National Nature Science Foundation of China (No. 81702884)

More Information

Corresponding author: Bo Fu; E-mail: fubo.22@163.com

摘要

摘要: 5-甲基胞嘧啶（5-methylcytosine，m⁵C）是RNA中重要的甲基化修饰之一，也是近年来的研究热点。随着甲基化测序技术的发展，在编码RNA及非编码RNA中均证实存在大量的m⁵C甲基化修饰。RNA m⁵C甲基化修饰受m⁵C甲基转移酶、去甲基化酶及m⁵C甲基化结合蛋白的调控。m⁵C甲基化修饰调节RNA的稳定性、转运、翻译和压力应激等，并参与调节肿瘤的发生发展、侵袭转移、肿瘤耐药等进程。本文对RNA m⁵C甲基化修饰的调控机制、功能以及在肿瘤中的研究进展进行综述，以期为肿瘤诊治研究提供新思路。
- m⁵C甲基化修饰 /
- 编码RNA /
- 非编码RNA /
- 肿瘤
Abstract: 5-methylcytosine (m⁵C) is an important post-translationally modified base in RNA formed by cytosine methylation. As the development of methylation sequencing techniques, extensive m⁵C modifications have been found in both coding and non-coding RNA. Incorporation of m⁵C into RNA is regulated by methyltransferases, demethylases, and m⁵C-binding proteins. m⁵C incorporation regulates RNA stability, transport, translation, and pressure stress. Recent studies have revealed that m⁵C incorporation into RNA is involved in the regulation of tumor pathogenesis, development, invasion, metastasis, and resistance. This article reviews m⁵C-mediated regulatory mechanisms and functions, and research progress on m⁵C-modified RNA functions in tumors, thus providing novel insights for developing innovative tumor diagnostic and therapeutic strategies.
- 5-methylcytosine (m⁵C) /
- encoding RNA /
- non-coding RNA /
- tumor

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参考文献(27)

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