王勤奋, 秦将均, 许有忠, 王平, 吴一清, 邓镇生, 李志伟, 陈丽娥. 99Tcm-异腈脱氧氨基葡萄糖SPECT/CT在肺癌诊断中的临床研究[J]. 中国肿瘤临床, 2021, 48(21): 1125-1128. DOI: 10.12354/j.issn.1000-8179.2021.20211158
引用本文: 王勤奋, 秦将均, 许有忠, 王平, 吴一清, 邓镇生, 李志伟, 陈丽娥. 99Tcm-异腈脱氧氨基葡萄糖SPECT/CT在肺癌诊断中的临床研究[J]. 中国肿瘤临床, 2021, 48(21): 1125-1128. DOI: 10.12354/j.issn.1000-8179.2021.20211158
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Qinfen Wang, Jiangjun Qin, Youzhong Xu, Ping Wang, Yiqing Wu, Zhengsheng Deng, Zhiwei Li, Li'e Chen. Clinical Research on 99Tcm-isonitrile deoxyglucosamine single photon emission computed tomography/computed tomography for lung cancer diagnosis[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2021, 48(21): 1125-1128. DOI: 10.12354/j.issn.1000-8179.2021.20211158
Citation: Qinfen Wang, Jiangjun Qin, Youzhong Xu, Ping Wang, Yiqing Wu, Zhengsheng Deng, Zhiwei Li, Li'e Chen. Clinical Research on 99Tcm-isonitrile deoxyglucosamine single photon emission computed tomography/computed tomography for lung cancer diagnosis[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2021, 48(21): 1125-1128. DOI: 10.12354/j.issn.1000-8179.2021.20211158
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99Tcm-异腈脱氧氨基葡萄糖SPECT/CT在肺癌诊断中的临床研究

Clinical Research on 99Tcm-isonitrile deoxyglucosamine single photon emission computed tomography/computed tomography for lung cancer diagnosis

    摘要
  • 摘要:
      目的  研究99Tcm-异睛脱氧氨基葡萄糖（99Tcm-isonitrile deoxyglucosamine，99Tcm-CN5DG）SPECT/CT对肺癌诊断和鉴别诊断的价值。
      方法  收集2019年7月至2021年1月于三亚中心医院（海南省第三人民医院）前瞻性研究95例经过手术、组织活检病理确诊（92例）或治疗后临床影像随访证实（3例）的肺病损（共97个）患者，99Tcm-CN5DG SPECT/CT采用目测法结合半定量法判断良恶性，强化CT则据肺病损形态特征判断良恶性。分析99Tcm-CN5DG SPECT/CT、强化CT对肺病损的诊断效能。
      结果  97个肺病损中80个恶性、17个良性。良恶性肺病损的靶和非靶摄取比值(target to non-target,T/NT) 分别为（1.49±0.86） vs. （3.25±1.72）差异有统计学意义（P<0.01）。99Tcm-CN5DG SPECT/CT诊断肺癌的灵敏度、特异性、准确性、阳性预测值、阴性预测值均高于强化CT（分别为97.5%、76.5%、93.8%、95.1%、86.7% vs. 87.5%、41.2%、79.4%、87.7%、41.2%），其中灵敏度、准确性、阴性预测值的差异有统计学意义（均P<0.05）。99Tcm-CN5DG SPECT/CT提供了优于强化CT的纵膈淋巴结分期、肿瘤边界勾画等重要信息。
      结论  99Tcm-CN5DG SPECT/CT是使用简便、价格低廉、安全有效的肺癌诊断和鉴别诊断方法。

     

    Abstract:
      Objective  To evaluate the clinical value of 99Tcm-isonitrile deoxyglucosamine single photon emission computed tomography/computed tomography (99Tcm-CN5DG SPECT/CT) for diagnosis and differential diagnosis of lung cancer.
      Methods  This prospective study included 95 patients with 97 confirmed lung lesions based on surgical (49 cases), tissue biopsy pathological examination (43 cases), or clinical imaging follow-up findings (three cases) in Sanya Central Hospital (The Third People’s Hospital of Hainan Province) from July 2019 to January 2021 . Visual and semi-quantitative methods were performed using 99Tcm-CN5DG SPECT/CT to evaluate benign and malignant lesions, and enhanced CT was performed to determine benign and malignant lesions based on morphological characteristics of the lesions. The efficacies of 99Tcm-CN5DG SPECT/CT and enhanced CT in diagnosing lung lesions were then analyzed.
      Results  Among the 97 lung lesions, 80 were malignant and 17 were benign. There was a significant difference in target to non-target (T/NT) values between benign and malignant lung lesions (1.49±0.86) vs. (3.25±1.72); P<0.01. To diagnose lung cancer, the sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of 99Tcm-CN5DG SPECT/CT were higher than those of enhanced CT (97.5%, 76.5%, 93.8%, 95.1%, and 86.7%, respectively vs. 87.5%, 41.2%, 79.4%, 87.7%, and 41.2%,respectively),indicating significant differences between the two modalities (P<0.05). Additionally, 99Tcm-CN5DG SPECT/CT provided better information on mediastinal lymph node staging and tumor boundary delineation than enhanced CT.
      Conclusions  Thus, 99Tcm-CN5DG SPECT/CT facilitates the diagnosis and differential diagnosis of lung cancer in a cost-effective, safe, and effective manner.

     

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