Rab27在消化系统肿瘤中的研究进展

李庆艳; 曾志艳; 肖文华; 关娜

doi:10.12354/j.issn.1000-8179.2022.20210418

Rab27在消化系统肿瘤中的研究进展

doi: 10.12354/j.issn.1000-8179.2022.20210418

李庆艳^1,,
曾志艳¹,
肖文华^{1, 2, ,},
关娜¹

1.
中国人民解放军总医院第四医学中心肿瘤内科（北京市100048）
2.
中国人民解放军总医院第五医学中心肿瘤内科

基金项目: 本文课题受国家自然科学基金项目（编号：81372220）和青年科学基金项目（编号：82001847）资助

详细信息

作者简介:
李庆艳：专业方向为消化道肿瘤临床诊断及基础治疗

通讯作者:
肖文华　w_hxiao@hotmail.com

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出版历程
- 收稿日期: 2021-03-09
- 录用日期: 2021-11-18
- 网络出版日期: 2022-01-18

Research progress on Rab27 in gastrointestinal cancer

Qingyan Li^1
,,
Zhiyan Zeng¹,
Wenhua Xiao^{1, 2
, ,},
Na Guan¹

1.
Department of Oncology, Fourth Medical Center of Chinese People's Liberation Army General Hospital, Beijing 100048, China
2.
Department of Oncology, Fifth Medical Center of Chinese People's Liberation Army General Hospital, Beijing 100039, China

Funds: This work was supported by the National Natural Science Fund Project (No.81372220) and Youth Science Fund Project (No.82001847)

More Information

Corresponding author: Wenhua Xiao; E-mail: w_hxiao@hotmail.com

摘要

摘要: Rab蛋白是一类小分子GTP结合蛋白，属于Ras蛋白超家族。目前，已经发现的Rab蛋白家族成员有70多个，广泛分布在多种生物细胞内不同的膜结构上，作为囊泡运输、蛋白质运输、膜靶向和融合的调节器，参与调节细胞生长、程序性死亡或凋亡。异常调控的Rab蛋白可通过破坏细胞膜运输、关键细胞信号通路和特殊分泌通路的稳态，进而影响癌症的细胞生理学。Rab27家族属于Rab蛋白家族，包括Rab27A和Rab27B两种亚型，二者具有相似但不相同的功能。Rab27A及Rab27B不但是调节囊泡运输的重要分子，而且与多种肿瘤的生长和侵袭转移有着紧密的联系，在肿瘤的治疗中可以作为治疗靶点和预后标志物。Rab27在肿瘤的发生发展中发挥重要作用。本文就Rab27在消化系统肿瘤中的研究进展进行综述。
- Rab27蛋白 /
- 消化道肿瘤 /
- 外泌体
Abstract: Rab proteins are small GTP-binding proteins belonging to the Ras protein superfamily. To date, more than 70 Rab family members have been identified that are distributed in a wide range of different membrane structures in various cell types. They act as regulators of vesicle transport, protein transport, and membrane targeting and fusion and participate in regulating cell growth and programmed death (apoptosis). A large number of studies have shown that abnormally-regulated Rab proteins affect cell physiology in cancer by disrupting homeostasis in cell membrane transport, key cell signaling pathways, and specialized secretion pathways. The Rab27 subfamily belongs to the Rab protein family and includes Rab27A and Rab27B,which have similar but not identical functions. Rab27A and Rab27B are not only important molecules in regulating vesicular transport but are also closely related to growth, invasion, and metastasis in a variety of tumors and can be used as therapeutic targets and prognostic markers in tumor therapy. Steadily increasing evidence shows that Rab27 plays an indispensable role in the occurrence and development of tumors. This article reviews research progress in investigations of Rab27 in digestive system tumors.
- Rab27 protein /
- digestive tract tumor /
- exosome

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