Abstract: Pyroptosis is the programmed cell death that relies on Gasdermin family proteins to induce the formation of pores in the plasma membrane of the cell, resulting in the production and release of IL-18 and IL-1 inflammatory factors. With the advances in research, the biological role of pyroptosis in cancer has become increasingly prominent. The key components of pyroptosis, especially the Gasdermin family, play an important role in the occurrence and development of cancer. The relationship between pyroptosis and gastric cancer is complicated. While pyroptosis can inhibit the occurrence and development of tumors, it can also, through pro-inflammatory death, form a suitable microenvironment for the growth of tumor cells, thereby promoting tumor growth. Therefore, this article explores the role of pyroptosis and its molecular mechanism in gastric cancer, to provide new ideas for its diagnosis and treatment.