自噬在菌群相关肿瘤中的研究进展

王宇; 刘超; 杜江; 周旋

doi:10.12354/j.issn.1000-8179.2022.20211224

自噬在菌群相关肿瘤中的研究进展

doi: 10.12354/j.issn.1000-8179.2022.20211224

天津医科大学肿瘤医院颌面耳鼻喉肿瘤科, 国家肿瘤临床医学研究中心, 天津市"肿瘤防治"重点实验室, 天津市恶性肿瘤临床医学研究中心（天津市300060）

基金项目: 本文课题受国家自然科学基金面上项目（编号：82002892，81872206，82073010）和天津市教委资助项目（编号：2019KJ188）资助

详细信息

作者简介:
王宇：专业方向为头颈肿瘤临床和基础转化性研究

通讯作者:
周旋　xuanzhou@tmu.edu.cn

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出版历程
- 收稿日期: 2021-08-01
- 网络出版日期: 2022-02-11

Research progress of autophagy in microbiota-associated tumors

Department of Maxillofacial and Otorhinolaryngology Oncology, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China

Funds: This work was supported by the National Natural Science Foundation of China General Project （No.82002892，No. 81872206，No. 82073010）, Tianjin Municipal Education Commission Support Grant （No. 2019KJ188）

More Information

Corresponding author: Xuan Zhou; E-mail: xuanzhou@tmu.edu.cn

摘要

摘要: 自噬是真核生物中高度保守的分解代谢过程，其实质是溶酶体依赖的蛋白质降解途径。自噬调节异常与许多肿瘤的发生发展密切相关，其既能促进肿瘤存活，亦能促进肿瘤消亡。研究表明菌群失调可通过促进黏膜炎症或引起全身疾病直接或间接导致肿瘤发生发展，并在调节免疫系统对肿瘤的反应中发挥作用。菌群失衡和自噬过程可通过多种分子机制联系在一起并通过这些途径影响肿瘤进展。本文旨在对自噬在菌群相关肿瘤中的关键作用进行综述，并探讨了自噬调节这一复杂生物学过程的分子机制；此外，本文还分析了以菌群/自噬生物轴为靶点的多种分子药物治疗肿瘤的可能性，对以自噬或菌群为靶点的临床试验进行总结并针对其作为抗癌策略的治疗潜力进行评价。
- 自噬 /
- 菌群 /
- 肿瘤发生 /
- 肿瘤进展
Abstract: Autophagy is a highly conserved catabolism process in eukaryotes, a lysosomal dependent protein degradation process. Aberrated autophagy regulation is closely related to the development of several human cancers, which can promote tumor survival as well as trigger tumor death. Concomitantly, flora disorders can also directly lead to cancer by promoting mucosal inflammation or causing systemic diseases. It plays a role in regulating the immune system's response to cancer. Multiple molecular mechanisms link dysbacteriosis with autophagy activation and influence tumor progression (pro-tumor or anti-tumor) through these pathways. The current review focuses on the critical role of autophagy in the interaction between microflora and cancer, and discusses the specific molecular mechanism of the regulation of autophagy in this complex biological process. In addition, we discussed the potential of multiple molecular drugs targeting the flora/autophagy axis for cancer treatment, reviewed clinical trials targeting autophagy or microbiome, and evaluated their therapeutic potential as anti-cancer strategies.
- autophagy /
- microflora /
- tumorigenesis /
- tumor progression

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