Abstract: Breast cancer is a high incidence and mortality cancer with high heterogeneity. Early accurate diagnosis and individualized treatment are effective means to improve the survival rate of patients. Molecular nuclear medicine imaging combines molecular biology technology with nuclear medicine, qualitative and quantitative studying the biological behavior of cancer in molecules, cells and living levels. It is a highly repeatable, safe and non-invasive imaging, which is widely used in the diagnosis, staging, prognosis prediction and efficacy evaluation of various malignant tumors. This article reviewed the molecular nuclear medicine of breast cancer, including metabolic, receptor, gene and immunoPET imaging.