Abstract: Solid tumor tends to resist chemotherapy, radiation and immunotherapy, which seriously affects the therapeutic effect. The application of low-intensity ultrasound to enhance tumor radiotherapy, chemotherapy and immunotherapy has always been a basic research hotspot in the field of ultrasound medicine. Yet the use of low-intensity diagnostic ultrasound to enhance tumor radiotherapy and chemotherapy would benefit from precise image guide, noninvasive and quick clinical translation. This paper reviews the mechanism of sonoporation with diagnostic ultrasound, and introduces the enhancement of tumor perfusion by ultrasound, the basic and clinical research of ultrasound-enhanced tumor chemoradiotherapy, immunotherapy, safety of ultrasound therapy and also the equipment modification of diagnostic ultrasound system.