Abstract: Epstein-Barr virus (EBV) is associated with human tumors. EBV can be detected in various epithelial, mesenchymal, and lymphohematopoietic tumors. EBV is closely related to lymphoma, especially the occurrence, development, and prognosis of Burkitt's lymphoma (BL), Hodgkin's lymphoma (HL), diffuse large B-cell lymphoma (DLBCL), post-transplant lymphoproliferative disorders (PTLD), NK/T-cell lymphoma, and other diseases. A large number of research reports and clinical data show that EBV and its encoded proteins and microRNAs play an important and complex role in inducing malignant transformation of lymphocytes, including proteins in various signaling pathways that promote proliferation and inhibit apoptosis. This study reviews the progress in research on EBV and the pathogenesis of lymphoma closely related to EBV infection in recent years to provide a theoretical basis for further understanding EBV infection and its mechanism of lymphoma.