Abstract: Neutrophils are static cells in blood circulation that play a phagocytic and bactericidal role when they are invaded by microorganisms. After neutrophils are activated, they form special reticular structures called neutrophil extracellular traps (NETs) that have recently been found to be a double-edged sword. Under normal circumstances, NETs play a role in eliminating pathogenic microorganisms. However, excessive NETs contribute to the development of diseases, such as autoimmune diseases, diabetes, atherosclerosis, and vasculitis. NETs are also closely related to the proliferation, metastasis,and prognosis of many kinds of malignant tumors. This article will review the literature on the formation of NETs and its effect on diffuse large B-cell lymphoma (DLBCL).