杨刚, 张乐杨, 周雨迪, 周启阳, 陈昕, 胡优, 周晓俊. 代谢综合征及其组份与结直肠癌根治术后短期预后的相关性[J]. 中国肿瘤临床, 2022, 49(19): 982-987. DOI: 10.12354/j.issn.1000-8179.2022.20211812
引用本文: 杨刚, 张乐杨, 周雨迪, 周启阳, 陈昕, 胡优, 周晓俊. 代谢综合征及其组份与结直肠癌根治术后短期预后的相关性[J]. 中国肿瘤临床, 2022, 49(19): 982-987. DOI: 10.12354/j.issn.1000-8179.2022.20211812
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Gang Yang, Leyang Zhang, Yudi Zhou, Qiyang Zhou, Xin Chen, You Hu, Xiaojun Zhou. Relationship between metabolic syndrome and its components and short-term outcome after radical resection of colorectal cancer[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2022, 49(19): 982-987. DOI: 10.12354/j.issn.1000-8179.2022.20211812
Citation: Gang Yang, Leyang Zhang, Yudi Zhou, Qiyang Zhou, Xin Chen, You Hu, Xiaojun Zhou. Relationship between metabolic syndrome and its components and short-term outcome after radical resection of colorectal cancer[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2022, 49(19): 982-987. DOI: 10.12354/j.issn.1000-8179.2022.20211812
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代谢综合征及其组份与结直肠癌根治术后短期预后的相关性

Relationship between metabolic syndrome and its components and short-term outcome after radical resection of colorectal cancer

    摘要
  • 摘要:
      目的  探讨代谢综合征（metabolic syndrome，MS）及其组份与结直肠癌根治术后的短期预后的关系。
      方法  收集苏州大学附属第一医院2013年1月至2018年12月行结直肠癌根治术的919例患者的临床病理资料，采用Logistic、Cox回归分析MS及其组分对结直肠癌患者术后短期并发症及生存的影响。
      结果  本研究中MS组的术后并发症的发生率（17.9%）较非MS组（11.5%）高（P=0.014）。单因素分析显示MS、高血压、高血糖影响结直肠癌术后并发症的发生（均P<0.05），多因素分析显示高血糖是术后发生并发症的独立危险因素（P<0.05）。生存分析发现，低高密度脂蛋白胆固醇（high density lipoprotein cholesterol，HDL-C）是结直肠癌术后生存期的危险因素(均P<0.05)；超重或肥胖是结直肠癌术后总生存期的保护因素（P=0.007）。
      结论  MS及其相关组份对结直肠癌术后并发症和生存有明显影响作用；MS及相关组份在短时间内难以控制满意，对结直肠癌预后影响较大，应当引起临床医生的重视。

     

    Abstract:
      Objective  To investigate the relationship between metabolic syndrome (MS) and its components and short-term prognosis after radical resection for colorectal cancer.
      Methods  Clinical data of 919 patients with colorectal cancer who underwent radical resection in The First Affiliated Hospital of Soochow University between January 2013 and December 2018 were collected. The effects of MS and its components on short-term postoperative complications and survival of patients with colorectal cancer were analyzed using Logistic and Cox regression.
      Results  The incidence of postoperative complications in the MS group (17.9%) was higher than that in the non-MS group (11.5%)(P=0.014). Univariate analysis showed that MS, hypertension, and hyperglycemia affected the occurrence of postoperative complications for colorectal cancer (all P<0.05). Multivariate analysis showed that hyperglycemia was the risk factor of postoperative complications (P<0.05). Survival analysis showed that low high density lipoprotein cholesterol (HDL-C) level was the risk factor for postoperative survival following colorectal cancer (P<0.05); overweight or obesity was a protective factor for overall postoperative survival (P=0.007).
      Conclusions  MS and its related components are difficult to control satisfactorily in a short period, have significant effects on postoperative complications and survival following colorectal cancer, and have a great impact on colorectal cancer prognosis, which should be focused on by clinicians.

     

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