Abstract:
Objective To investigate the relationship between metabolic syndrome (MS) and its components and short-term prognosis after radical resection for colorectal cancer.
Methods Clinical data of 919 patients with colorectal cancer who underwent radical resection in The First Affiliated Hospital of Soochow University between January 2013 and December 2018 were collected. The effects of MS and its components on short-term postoperative complications and survival of patients with colorectal cancer were analyzed using Logistic and Cox regression.
Results The incidence of postoperative complications in the MS group (17.9%) was higher than that in the non-MS group (11.5%)(P=0.014). Univariate analysis showed that MS, hypertension, and hyperglycemia affected the occurrence of postoperative complications for colorectal cancer (all P<0.05). Multivariate analysis showed that hyperglycemia was the risk factor of postoperative complications (P<0.05). Survival analysis showed that low high density lipoprotein cholesterol (HDL-C) level was the risk factor for postoperative survival following colorectal cancer (P<0.05); overweight or obesity was a protective factor for overall postoperative survival (P=0.007).
Conclusions MS and its related components are difficult to control satisfactorily in a short period, have significant effects on postoperative complications and survival following colorectal cancer, and have a great impact on colorectal cancer prognosis, which should be focused on by clinicians.