脊柱转移瘤的外科治疗进展

朱小军; 宋国徽; 唐清连; 卢金昌; 吴昊; 吴萍; 王晋

doi:10.12354/j.issn.1000-8179.2022.20220018

脊柱转移瘤的外科治疗进展

doi: 10.12354/j.issn.1000-8179.2022.20220018

中山大学肿瘤防治中心骨与软组织科（广州市510060）

基金项目: 本文课题受国家自然科学基金面上项目（编号：81872268）资助

详细信息

作者简介:
朱小军：专业方向为骨与软组织肿瘤外科治疗

通讯作者:
王晋 wangjinbs@sysucc.org.cn

计量
- 文章访问数: 130
- HTML全文浏览量: 56
- PDF下载量: 38
- 被引次数: 0
出版历程
- 收稿日期: 2022-01-05
- 录用日期: 2022-04-02

Research progress on surgical treatment of spinal metastases

Department of Musculoskeletal Oncology, Sun Yat-sen University Cancer Center, Guangzhou 510060, China

Funds: This wrok was supported by the National Natural Science Foundation of China (No. 81872268)

More Information

Corresponding author: Wang Jin; E-mail: wangjinbs@sysucc.org.cn

摘要

摘要: 骨是肿瘤继肺、肝之后第三大转移部位。随着相关学科的发展、多学科治疗模式的推进，尤其是靶向药物和免疫药物取得的进展，肿瘤患者生存期逐渐延长，出现骨转移概率逐渐增大，尤其是脊柱转移，严重影响患者的生活质量和预后。有关脊柱转移瘤的治疗，近年临床研究取得了较大的进展，治疗模式不断发生变化。在外科治疗方面，外科手术微创化，影像导航下的内镜手术或机器人协助下的微创手术逐渐成为未来发展的趋势。
- 脊柱转移瘤 /
- 外科治疗 /
- 立体定向放疗 /
- 微创手术 /
- 消融
Abstract: Bone is the third most common metastasis site after the lung and liver. With the development of related disciplines and multidisciplinary treatment models, especially the progression of targeted and immune drugs, the survival period of patients with tumor is gradually increasing. The increasing probability of bone metastases, especially spinal metastases, seriously affects the quality of life and prognosis of patients. Clinical research has made great progress in recent years regarding the treatment of spinal metastases, and the treatment mode has changed. Surgical treatments are gradually becoming less invasive, and endoscopic surgery under imaging navigation and minimally invasive robot-assisted surgery are gaining prominence.
- spinal metastases /
- surgical treatment /
- stereotactic body radiotherapy /
- minimal invasive operation /
- ablation

HTML全文

参考文献(34)

[1]	Klekamp J, Samii H. Surgical results for spinal metastases[J]. Acta Neurochir (Wien), 1998, 140(9):957-967. doi: 10.1007/s007010050199
[2]	Patchell RA, Tibbs PA, Regine WF, et al. Direct decompressive surgical resection in the treatment of spinal cord compression caused by metastatic cancer: a randomised trial[J]. Lancet, 2005, 366(9486):643-648.
[3]	Tomita K, Toribatake Y, Kawahara N, et al. Total en bloc spondylectomy and circumspinal decompression for solitary spinal metastasis[J]. Paraplegia, 1994, 32(1):36-46.
[4]	Tomita K, Kawahara N, Baba H, et al. Total en bloc spondylectomy for solitary spinal metastases[J]. Int Orthop, 1994, 18(5):291-298.
[5]	Boriani S, Bandiera S, Donthineni R, et al. Morbidity of en bloc resections in the spine[J]. Eur Spine J, 2010, 19(2):231-241. doi: 10.1007/s00586-009-1137-z
[6]	Kieser DC, Parker J, Reynolds J. En bloc resection of isolated spinal metastasis: a systematic review update[J]. Clin Spine Surg, 2021, 34(3):103-106. doi: 10.1097/BSD.0000000000001057
[7]	Kato S, Demura S, Shinmura K, et al. Surgical metastasectomy in the spine: a review article[J]. Oncologist, 2021, 26(10):e1833-e1843. doi: 10.1002/onco.13840
[8]	Howell EP, Williamson T, Karikari I, et al. Total en bloc resection of primary and metastatic spine tumors[J]. Ann Transl Med, 2019, 7(10):226. doi: 10.21037/atm.2019.01.25
[9]	Boriani S, Gasbarrini A, Bandiera S, et al. Predictors for surgical complications of en bloc resections in the spine: review of 220 cases treated by the same team[J]. Eur Spine J, 2016, 25(12):3932-3941. doi: 10.1007/s00586-016-4463-y
[10]	Bilsky MH, Laufer I, Fourney DR, et al. Reliability analysis of the epidural spinal cord compression scale[J]. J Neurosurg Spine, 2010, 13(3):324-328. doi: 10.3171/2010.3.SPINE09459
[11]	Barzilai O, Laufer I, Robin A, et al. Hybrid therapy for metastatic epidural spinal cord compression: technique for separation surgery and spine radiosurgery[J]. Oper Neurosurg (Hagerstown), 2019, 16(3):310-318. doi: 10.1093/ons/opy137
[12]	Laufer I, Iorgulescu JB, Chapman T, et al. Local disease control for spinal metastases following “separation surgery” and adjuvant hypofractionated or high-dose single-fraction stereotactic radiosurgery: outcome analysis in 186 patients[J]. J Neurosurg Spine, 2013, 18(3):207-214.
[13]	Guckenberger M, Mantel F, Gerszten PC, et al. Safety and efficacy of stereotactic body radiotherapy as primary treatment for vertebral metastases: a multi-institutional analysis[J]. Radiat Oncol, 2014, 9:226. doi: 10.1186/s13014-014-0226-2
[14]	Yamada Y, Katsoulakis E, Laufer I, et al. The impact of histology and delivered dose on local control of spinal metastases treated with stereotactic radiosurgery[J]. Neurosurg Focus, 2017, 42(1):E6. doi: 10.3171/2016.9.FOCUS16369
[15]	Blakaj DM, Palmer JD, Dibs K, et al. Postoperative stereotactic body radiotherapy for spinal metastasis and predictors of local control[J]. Neurosurgery, 2021, 88(5):1021-1027. doi: 10.1093/neuros/nyaa587
[16]	Lykissas MG, Giannoulis D. Minimally invasive spine surgery for degenerative spine disease and deformity correction: a literature review[J]. Ann Transl Med, 2018, 6(6):99. doi: 10.21037/atm.2018.03.18
[17]	Versteeg AL, Verlaan JJ, de Baat P, et al. Complications after percutaneous pedicle screw fixation for the treatment of unstable spinal metastases[J]. Ann Surg Oncol, 2016, 23(7):2343-2349.
[18]	Hansen-Algenstaedt N, Kwan MK, Algenstaedt P, et al. Comparison between minimally invasive surgery and conventional open surgery for patients with spinal metastasis: a prospective propensity score-matched study[J]. Spine, 2017, 42(10):789-797.
[19]	Lu VM, Alvi MA, Goyal A, et al. The potential of minimally invasive surgery to treat metastatic spinal disease versus open surgery: a systematic review and meta-analysis[J]. World Neurosurg, 2018, 112:e859-e868. doi: 10.1016/j.wneu.2018.01.176
[20]	Zhu XJ, Lu JC, Xu HY, et al. A comparative study between minimally invasive spine surgery and traditional open surgery for patients with spinal metastasis[J]. Spine, 2021, 46(1):62-68. doi: 10.1097/BRS.0000000000003690
[21]	Pranata R, Lim MA, Vania R, et al. Minimal invasive surgery instrumented fusion versus conventional open surgical instrumented fusion for the treatment of spinal metastases: a systematic review and meta-analysis[J]. World Neurosurgery, 2021, 148:e264-e274. doi: 10.1016/j.wneu.2020.12.130
[22]	Alshareef M, Klapthor G, Alawieh A, et al. Evaluation of open and minimally invasive spinal surgery for the treatment of thoracolumbar metastatic epidural spinal cord compression: a systematic review[J]. Eur Spine J, 2021, 30(10):2906-2914.
[23]	Vega RA, Ghia AJ, Tatsui CE. Percutaneous hybrid therapy for spinal metastatic disease: laser interstitial thermal therapy and spinal stereotactic radiosurgery[J]. Neurosurg Clin N Am, 2020, 31(2):211-219. doi: 10.1016/j.nec.2019.11.006
[24]	Bastos DCA, Vega RA, Traylor JI, et al. Spinal laser interstitial thermal therapy: single-center experience and outcomes in the first 120 cases[J]. J Neurosurg Spine, 2020:1-10.
[25]	de Almeida Bastos DC, Everson RG, de Oliveira Santos BF, et al. A comparison of spinal laser interstitial thermotherapy with open surgery for metastatic thoracic epidural spinal cord compression[J]. J Neurosurg Spine, 2020:1-9.
[26]	Tatsui CE, Lee SH, Amini B, et al. Spinal laser interstitial thermal therapy: a novel alternative to surgery for metastatic epidural spinal cord compression[J]. Neurosurgery, 2016, 79(Suppl 1):S73-S82.
[27]	Luigi Cazzato R, Auloge P, de Marini P, et al. Percutaneous image-guided ablation of bone metastases: local tumor control in oligometastatic patients[J]. Int J Hyperthermia, 2018, 35(1):493-499. doi: 10.1080/02656736.2018.1508760
[28]	Sagoo NS, Haider AS, Rowe SE, et al. Microwave ablation as a treatment for spinal metastatic tumors: a systematic review[J]. World Neurosurg, 2021, 148:15-23. doi: 10.1016/j.wneu.2020.12.162
[29]	Filippiadis D, Kelekis A. Percutaneous bipolar radiofrequency ablation for spine metastatic lesions[J]. Eur J Orthop Surg Traumatol, 2021, 31(8):1603-1610. doi: 10.1007/s00590-021-02947-9
[30]	Delpla A, Tselikas L, de Baere T, et al. Preventive vertebroplasty for long-term consolidation of vertebral metastases[J]. Cardiovasc Intervent Radiol, 2019, 42(12):1726-1737. doi: 10.1007/s00270-019-02314-6
[31]	Tsai SH, Wu HH, Cheng CY, et al. Full endoscopic interlaminar approach for nerve root decompression of sacral metastatic tumor[J]. World Neurosurg, 2018, 112:57-63.
[32]	Solomiichuk V, Fleischhammer J, Molliqaj G, et al. Robotic versus fluoroscopy-guided pedicle screw insertion for metastatic spinal disease: a matched-cohort comparison[J]. Neurosurg Focus, 2017, 42(5):E13. doi: 10.3171/2017.3.FOCUS1710
[33]	Sayari AJ, Pardo C, Basques BA, et al. Review of robotic-assisted surgery: what the future looks like through a spine oncology lens[J]. Ann Transl Med, 2019, 7(10):224. doi: 10.21037/atm.2019.04.69
[34]	Court C, Boulate D, Missenard G, et al. Video-assisted thoracoscopic en bloc vertebrectomy for spine tumors: technique and outcomes in a series of 33 patients[J]. J Bone Joint Surg Am, 2021, 103(12):1104-1114. doi: 10.2106/JBJS.20.01417