Abstract:
Objective To investigate the clinical efficacy and safety of bortezomib, cyclophosphamide, and dexamethasone (BCD) for the treatment of newly diagnosed multiple myeloma (MM).
Methods We retrospectively analyzed 131 patients from April 2008 to August 2017, who were newly diagnosed MM and had enrolled in Institute of Hematology & Blood Diseases Hospital.
Results The median age of the patients was 58 years, and 27.3% patients (24/88) aged ≤65 years underwent autologous hematopoietic stem cell transplantation. The overall response rate (ORR) was 88.5%, the median progression-free survival (PFS) was 36.0 months, and the median overall survival (mOS) was 63.0 months. IgH/FGFR3 translocation showed no adverse effects on the ORR or survival (PFS or OS). The most common non-hematological toxicities were infection, peripheral neuritis (PN), and gastrointestinal events. Of the observed hematological toxicities, Common Terminology Criteria for Adverse Events (CTCAE) grade 3/4 neutropenia occurred in 25.4% of patients and CTCAE grade 3/4 thrombocytopenia occurred in 27.2% of patients.
Conclusions BCD, as induction therapy, achieved remission in more than 80% of patients with newly diagnosed MM. IgH/FGFR3 translocation showed no adverse effects on treatment efficacy or patient survival. Based on the results of previous studies, low dose fractional application of cyclophosphamide is markedly safer than BCD.