Objective  To analyze the clinical efficacy of laparoscopic intragastric surgery (LIGS) for submucosal tumors and explore its safety, feasibility, and clinical application value.

  Methods  The clinical data of 12 patients with submucosal tumors treated by laparoscopic-assisted gastric gas injection in Hubei Minzu University Affiliated Hospital from January 2015 to May 2021 were retrospectively analyzed to evaluate the safety and feasibility of the treatment method for gastric submucosal tumors.

  Results  All 12 cases had successful completion of the surgery, and no abdominal surgery was performed. Gastric wall perforation was observed in one case. Then, intragastric wedge resection was performed, and the defect was closed by full-layer stitching. The surgery time ranged from 40 to 120 min, average time was 80 min; blood loss was 10 to 100 mL, and average blood loss was 40 mL. Postoperatively, no complications, such as bleeding, anastomosis fistula, cardiac stenosis, acid reflux, and other complications occurred. The gastric tube was removed and drinking water was extracted on the first to second day postoperatively, and liquid diet was taken on the second to third day postoperatively. The indwelling time of the drainage tube was 3–5 days, and the length of hospital stay was 5–7 days. Postoperative pathology indicated that one case was leiomyoma, and the rest were stromal tumors with a diameter of 17–56 mm and circumferential resection margin of 5–20 mm. After 6–12 months postoperatively, 12 cases underwent gastroscopy, which showed that the surgical site healed well, without ulcer and scar formation, and no tumor recurrence.

  Conclusions  Laparoscopic-assisted gastric gas injection is safe and feasible in gastric submucosal tumor treatment, which further reduces the surgical trauma of patients and preserves the organ function well.