Abstract:
Objective To explore the clinical characteristics and prognostic factors of parotid gland carcinoma.
Methods The clinical data of 151 patients with pathologically confirmed parotid gland carcinoma at Tianjin Medical University Cancer Institute & Hospital from January 2011 to October 2018 were collected. The patients’ clinicopathological features and survival outcomes were analyzed retrospectively.
Results The pathological types identified in 151 patients with parotid gland carcinoma included: mucoepidermoid carcinoma, acinic cell carcinoma, salivary duct carcinoma, adenoid cystic carcinoma, and adenocarcinoma. The pathological type (P=0.001), age (P=0.049), facial paralysis (P<0.001), microscopic nerve invasion (P<0.001), TNM stage (P<0.001), clinical stage (P<0.001), tumor recurrence (P<0.001), and postoperative adjuvant radiotherapy (P<0.001) were associated with prognosis in patients with parotid gland carcinoma. Moreover, tumor recurrence (P=0.001) and clinical stage (P=0.004) were the main prognostic factors of parotid gland carcinoma.
Conclusions Tumor recurrence and clinical stage were found to be independent prognostic risk factors in patients with parotid gland carcinoma. This provides important basis for estimating the disease prognosis and formulating individualized treatment plans.