Abstract:
Objective To explore the correlation between immunohistochemical indicators and traditional Chinese medicine (TCM) syndrome differentiation in localized high-risk prostate cancer.
Methods The clinical data of 50 patients with localized high-risk prostate cancer undergoing treatment at the First Teaching Hospital of Tianjin University of Traditional Chinese Medicine and the Tianjin Medical University General Hospital between January and December 2019 were collected. Immunohistochemical indicators such as chromogranin A (CgA) and synaptophysin (Syn), which are markers of neuroendocrine cells, and the Ki-67 index, which is a marker of proliferative cell activity, were used to analyze the clinical TCM syndrome differentiation based on the tongue coating and pulse symptoms of patients, combined with local and systemic symptoms.
Result In patients with localized high-risk prostate cancer, an increased Ki-67 index was the most common condition (P<0.05). Among the 50 patients, the dampness–heat accumulation and the liver–kidney Yin deficiency syndromes were the most common TCM syndrome differentiation (P<0.05). The dampness–heat accumulation syndrome was correlated with increased Ki-67 index and positive CgA, and the internal syndrome of stasis and toxin was correlated with increased Ki-67 index and positive Syn, suggesting that the prognosis of the two syndromes is poor (P<0.05).
Conclusions Patients with localized high-risk prostate cancer with differentiation of the dampness–heat accumulation syndrome and the internal syndrome of stasis and toxin showed neuroendocrine differentiation in tumor tissues, high cell proliferation activity, increased tumor malignancy, and rapid proliferation. On the basis of the endocrine therapy of western medicine, we should combine TCM syndrome differentiation as soon as possible, give full play to the advantages of TCM syndrome differentiation in treatment, and delay the progress of disease as much as possible.On the basis of the endocrine therapy of western medicine, we should combine TCM syndrome differentiation as soon as possible, give full play to the advantages of TCM syndrome differentiation in treatment, and delay the progress of disease as much as possible.
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