Abstract: Management of colorectal cancer peritoneal metastasis (CRCPM) has long been one of the key areas in clinical oncology of The Netherlands. compared with the palliative surgery plus systemic chemotherapy, the CRCPM patients were better treated with cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC). Since then, the high-level clinical evidence has laid the foundation for adopting CRS+HIPEC to treat CRCPM. The Dutch National Cancer Registry has been established and regularly updated through the sustained efforts and detailed information on PM from various primary malignancies is available for academic research. This paper presented the most recent studies in CRCPM, including epidemiology research, multicenter randomized clinical trials, basic and translational researches, the Dutch answers to the recent hot topics and international debates. The new opportunities and new directions for the future are also highlighted.