Abstract: Liver cancer is the fifth most common malignant tumor and the second leading cause of tumor-related deaths in China, and it severely jeopardizes the health and lives of individuals. Existing guidelines for liver cancer diagnosis and treatment do not consider the disease background of liver cancer in China, regional differences in diagnosis and treatment resources, and social value of cancer treatment; therefore, achieving individualized decision-making is challenging. The General Association of the China Anti-Cancer Association organized authoritative medical oncology experts nationwide to participate in the preparation of the Guidelines for Holistic Integrative Management of Liver Cancer, which adopts the structure of “prevention-screening-diagnosis-treatment-rehabilitation” and focuses on the prevention, treatment, and rehabilitation of patients with liver cancer, including epidemiology; screening; imaging examination; pathological assessment; multidisciplinary integrated treatments, such as surgical treatment, interventional treatment, systemic drug therapy, and radiotherapy; and whole-course rehabilitation management of liver cancer. The guideline is supposed to provide the most effective references for practitioners to achieve the best outcomes for patients with liver cancer.