急性髓系白血病细胞与骨髓基质细胞相互作用的研究进展

Research progress on the interaction between acute myeloid leukemia cells and bone marrow stromal cells

摘要: 骨髓微环境（bone marrow microenvironment，BMM）在急性髓系白血病（acute myeloid leukemia，AML）的发生发展中发挥重要作用，骨髓基质细胞（bone marrow stromal cells，BMSCs）是骨髓微环境中一类非造血细胞群，在正常造血与恶性血液肿瘤的发生发展中发挥关键作用。一方面，BMSCs调控AML细胞的增殖、凋亡及耐药，影响白血病进程；另一方面，AML细胞通过影响BMSCs的功能，反过来支持自身发生发展。二者相互作用，共同促进AML的进展。本文对近年来AML细胞与BMSCs相互作用的研究进展进行综述。

Abstract: The bone marrow microenvironment (BMM) plays an important role in the development of acute myeloid leukemia (AML). Bone marrow stromal cells (BMSCs) are a type of non-hematopoietic cell population found in BMM; they are crucial for the development of normal hematopoiesis and hematological malignancies. On the one hand, BMSCs regulate the proliferation, apoptosis, and drug resistance of AML cells and in turn, affect the progression of leukemia. On the other hand, AML cells promote their own development by affecting the characteristics of BMSCs. As a result, they interact to promote the progression of AML. In this paper, the recent research progress made regarding the interaction between AML cells and BMSCs has been reviewed.