Abstract:
Objective To investigate the effect of different metastatic sites on the prognosis of patients with high-grade node-negative upper tract urothelial carcinoma (UTUC) after radical nephroureterectomy (RNU).
Methods The clinical data of 355 patients with high-grade node-negative UTUC confirmed by pathology after RNU in Harbin Medical University Cancer Hospital from February 2010 to December 2020 were retrospectively analyzed. Univariate and multivariate analyses of prognostic factors were performed using Cox proportional hazards regression model.
Results Of the 355 patients, 77 (21.7%) had metastasis and 93 (26.1%) died. The median follow-up time was 45 months, and the median age was 67 years. The median overall survival (OS) of patients with liver, bone, and multiple metastases was 6, 6, and 5 months, respectively. Cox proportional hazards regression model multivariate analysis showed that intravesical recurrence (IVR), tumor size ≥ 2 cm, pathologic tumor stage > T2 are independent predictors of metastasis.
Conclusions The prognosis of UTUC patients with liver metastasis, bone metastasis and multiple metastasis is relatively poor, while the prognosis of lung metastasis and lymph node metastasis is relatively good. The efficacy of concurrent chemoradiotherapy and chemotherapy combined with immunotherapy in advanced UTUC patients with metastasis is better than that of untreated patients, radiotherapy alone, and chemotherapy alone.