Abstract: The endosomal sorting complex required for transport (ESCRT) plays an important role in several events involving membrane remodeling, including viral budding, cell division, neuronal pruning, and multivesicular body formation. ESCRT contains different subunits working cooperatively to carry out its biological function. ESCRT mutations or changes in its expression level may cause damage to membrane repair-related biological processes, leading to disorders such as Parkinson’s disease, AIDS, or tumors. Tumorigenesis is related to several membrane remodeling events; moreover, ESCRT has been shown to play an important role in tumor occurrence, development, treatment, and prognosis. This review mainly focuses on the different roles of ESCRT in tumorigenesis, including the mechanism of action, prognosis assessment, and selection of therapeutic targets. Further, it aims to provide insight into the relationship between ESCRT and tumors and suggest more options for tumor treatment.