Objective  To explore the correlation between homocysteine (HCY), coagulation function, incidence risk, and clinicopathologic features of colorectal cancer.

  Method  A total of 481 patients with colon cancer admitted to Tianjin Medical University Cancer Institute & Hospital from January 2021 to December 2021 were selected as the case group, and 126 patients with colorectal benign lesions were selected as the control group. T test, Chi-square test, Logistic regression analysis and other statistical methods were used to analyze the clinicopathological features, HCY and coagulation function between the two groups.

  Results  The levels of HCY, activated partial thromboplastin time (APTT), fibrinogen (Fbg), factor Ⅷ (F-Ⅷ), fibrinogen degradation product (FDP), D-dimer (D-D), and platelets (PLT) in colorectal cancer patients were higher (P<0.05), whereas the levels of thrombin time (TT) and protein C (PC) were lower than those in control group（P<0.05). HCY, PT, APTT, Fbg, TT, PC, F-Ⅷ, FDP, D-D, and PLT were the risk factors of colorectal cancer (P<0.05). The levels of F-Ⅷ, FDP, D-D, and PLT in right colon cancer were higher than those in left colon cancer and rectal cancer (P<0.05). Additionally, the levels of PT (SEC), PT (INR), APTT, Fbg, F-Ⅷ, D-D and PLT were significantly correlated with the size of the tumor (P<0.01). The levels of PT (SEC), PT(INR), Fbg, F-Ⅷ, D-D, and PLT in poorly differentiated patients were higher than those in middle and highly differentiated patients (P<0.05). Moreover, the levels of HCY, PT (INR), and PLT in stages Ⅲ and Ⅳ patients were higher than those in stages I and Ⅱ patients.

  Conclusions  Abnormal HCY and coagulation function indexes were positively correlated with the risk of colorectal cancer and closely correlated with the clinicopathologic features, TNM stage, and clinical stage of patients with colorectal cancer. Therefore, these factors can indicate the risk of disease and monitor the prognosis to a certain extent.