Abstract:
Immune checkpoint inhibitors (ICIs) have emerged as important targets of treatment for various types of cancers, yet drug resistance poses considerable problems. Tumor immunotherapy resistance is closely related to the tumor microenvironment (TME). Exhaustion of CD8
+T cells in the TME continuously express high levels of inhibitory receptors (IRs) and play a central role in ICIs resistance. Targeting IRs provides new prospects for overcoming immunotherapy resistance. This review focuses on the occurrence and characteristics of CD8
+T cell exhaustion and explores its association with tumor immunotherapy resistance.