肿瘤相关性高内皮微静脉在肿瘤治疗中角色的研究进展

Research progress on the role of tumor-associated high endothelial venules in anti-tumor therapy

摘要: 在恶性肿瘤中发现的表型类似于次级淋巴器官（secondary lymphoid organ， SLO）中高内皮微静脉（high endothelial venules，HEVs）的血管被称为肿瘤相关性高内皮微静脉（tumor-associated high endothelial venules，TA-HEVs），其在肿瘤中的形成与次级淋巴器官中HEVs的形成机制相似。TA-HEVs在促使淋巴细胞浸润肿瘤组织的过程中发挥了重要作用。随着对TA-HEVs研究深入，其在放疗、化疗、免疫治疗及抗血管生成治疗等抗肿瘤治疗中发挥积极作用，TA-HEVs的临床价值逐步凸显，本文将对其相应的机制、通路等进行综述。

Abstract: Malignant tumor blood vessels, with phenotypes that are similar to high endothelial venules (HEVs) in secondary lymphoid organs (SLO), are known as tumor-associated high endothelial venules (TA-HEVs). The formation mechanism of TA-HEVs is similar to that of HEVs. Moreover, TA-HEVs play an important role in promoting the infiltration of lymphocytes into tumor tissues. With ongoing research, the positive effect of TA-HEVs in the context of radiotherapy, chemotherapy, immunotherapy, and antiangiogenic therapy is being elucidated. The clinical value is gradually becoming prominent, and the mechanisms and pathways involved with TA-HEVs are still under investigation.