Abstract:
Objective:To observe vasculogenic mimicry in testicular germ cell malignant tumor and to in -vestigate the mechanism and clinical significance of vasculogenic mimicry in testicular germ cell malignant tu -mors.Methods:Forty cases of testicular germ cell malignant tumor with adequate clinical and pathological da-ta were enrolled. The presence of vasculogenic mimicry was observed by immunohistochemical and histo -chemical double staining of CD34and PAS. The clinical significance of vasculogenic mimicry was assessed. Results: VM channels were found in22of the 40cases of testicular germ cell malignant tumor. Analysis using
the Chi-sqaure test showed no statistical significance of VM positive rate in patients with different tumor size, metastasis or survival status (P=0.013 , P=0.045 , and P=0.000 ). Kaplan-Meier survival analysis showed that the presence of VM had a negative influence on prognosis (P=0.0127). Cox's proportional hazards model analysis indicated that the presence of VM was significant in predicting patient survival (P=0.038 , OR=4.043 ). Conclusion:VM exists in testicular germ cell malignant tumor and is a risk factor influencing prognosis. Pa-tients with VM have poorer prognosis than those without VM.