Abstract:
Objective: To investigate the clinical value of detecting serum VEGF, CEA, CA125 , and Cy-fra21-1 in non-small cell lung cancer (NSCLC) patients, and to explore the relationship between these levels and prognosis. Methods:In 78NSCLC patients, the serum VEGF levels were detected by ELISA, and the se-rum levels of CEA, CA 125 , and Cyfra21-1 were detected by radioimmunoassay before chemotherapy.Results: Serum levels of VEGF, CA125 and CEA were significantly higher in NSCLC patients with lymph node metastasis or other distant metastasis than in those without lymph node metastasis or other distant metasta-sis ( P<0.05). Serum levels of VEGF, CEA and CA125 were significantly higher in stage Ⅰand ⅡNSCLC pa -tients than in stage Ⅲand ⅣNSCLC patients ( P<0.05). Serum CEA levels were higher in patients with ade -nocarcinoma than in patients with other malignancies ( P<0.05). The chemotherapy response rate of NSCLC patients without VEGF or CEA expression was higher than that of those with VEGF (35.3% vs. 7.7% ,P= 0.004 ) or CEA ( 35.7% vs. 15.8% ,P=0.006 ) expression. The mean overall survival of CEA negative NSCLC patients was longer than those with CEA expression ( 36m vs. 20m,P=0.04). Serum levels of VEGF (P=0.07), Cyfra 21-1 (P=0.099 ), and CA 125 (P=0.19) were not correlated with overall survival. Serum levels of CEA (P=0.119 ), VEGF ( P=0.280 ), Cyfra 21-1 (P=0.146 ) and CA125 (P=0.230 ) were not correlated with mean time to progression of NSCLC. A positive correlation was observed between serum VEGF level and serum CEA level. No correlation was found among serum levels of CA125 , Cyfra21-1 and VEGF. Conclusion:The dectection of serum tumor markers in NSCLC patients before chemotherapy may be helpful for diagnosis, prediction of metastasis, chemotherapy response rate, and judgment of prognosis.