吴 倩, 朱志图, 哈敏文. BAG-1 在非小细胞肺癌中的表达与含铂方案化疗敏感性的关系*[J]. 中国肿瘤临床, 2009, 36(2): 97-100. DOI: 10.3969/j.issn.1000-8179.2009.02.010
引用本文: 吴 倩, 朱志图, 哈敏文. BAG-1 在非小细胞肺癌中的表达与含铂方案化疗敏感性的关系*[J]. 中国肿瘤临床, 2009, 36(2): 97-100. DOI: 10.3969/j.issn.1000-8179.2009.02.010
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WU Qian, ZHU Zhitu, HA Minwen. Correlation between the Expression of BAG-1 and Sensitivity to Platinum-based Chemotherapeutics in NSCLC[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2009, 36(2): 97-100. DOI: 10.3969/j.issn.1000-8179.2009.02.010
Citation: WU Qian, ZHU Zhitu, HA Minwen. Correlation between the Expression of BAG-1 and Sensitivity to Platinum-based Chemotherapeutics in NSCLC[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2009, 36(2): 97-100. DOI: 10.3969/j.issn.1000-8179.2009.02.010
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BAG-1 在非小细胞肺癌中的表达与含铂方案化疗敏感性的关系*

Correlation between the Expression of BAG-1 and Sensitivity to Platinum-based Chemotherapeutics in NSCLC

    摘要
  • 摘要: 目的：研究BAG-1 在非小细胞肺癌（non-small cell lung cancer ，NSCLC ）中的表达与临床特征及含铂方案化疗敏感性的关系，探讨NSCLC 的铂类耐药机制。方法：应用免疫组化的方法检测125 例NSCLC 术后石蜡标本中BAG-1 蛋白的表达情况，其中75例术后给予含铂方案化疗、50例单独行手术治疗，随访后进行生存预后分析。结果：1）BAG-1 在NSCLC 中存在高表达（阳性率为64.8%）；2）BAG-1 表达水平与组织学分级相关，分级越差其阳性率越高（P=0.024、0.042），与其它临床特征之间差异均无统计学意义；3）BAG-1 阳性组具有生存优势，且在胞浆中的表达具有更低的死亡风险（P=0.039）；4）BAG-1 阳性组在接受含铂方案化疗后不能明显延长生存时间，阴性组更能从中受益（P=0.048）。 结论：BAG-1 与铂类药物化疗敏感性相关，可能成为新型的临床预后指标，有助于NSCLC 个体化治疗方案的选择。

     

    Abstract: Objective:To detect the correlation of the expression of BAG-1 with clinical features and sensi-tivity to platinum-based chemotherapy of non-small cell lung cancer (NSCLC), and to further investigate the mechanism of resistance to platinum.Methods:The expression of BAG-1 was measured by immunohisto-chemistry in paraffin sections of125 NSCLC patients treated with surgery. Seventy-five of the125 patients re -ceived postoperative platinum–based chemotherapy. Results: BAG 1 was highly expressed in NSCLC sam -ples, with a positive rate of 64.8% . BAG-1 expression was correlated with histological grade. Samples from patients with poorer histological grade had higher BAG-1 expression. No correlation was found between BAG-1 expression and other clinical characteristics. Patients with BAG- 1 expression had better survival com -pared with those without BAG- 1 expression (P=0.039 ). Platinum-based chemotherapy didn ’t not prolong sur -vival time in patients with BAG- 1 expression but benefited those without BAG- 1 expression (P=0.048 ). Conclusion: BAG-1 protein expression is correlated with the NSCLC patients ’sensitivity to platinum-based chemo-therapy. BAG- 1 protein can be a new prognostic indicator and is helpful for developing individualized treat-ment for NSCLC.

     

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