Abstract:
Objective:To investigate the association between polymorphisms of FGFR 2 and the susceptibility of breast cancer in Han population in Guizhou province.Methods:Genotyping was performed using PCR-se-quence-specific primers (PCR-SSP) in 106 histologically confirmed breast cancer cases and 116 cancer-free controls. Results: The genotype frequencies of rs 1219648 TT, TC, and CC were 50%,25.47%, and24.53% in breast cancer cases and 29.31%,48.28%, and22.41% in the controls. The gene frequencies of T in breast cancer cases and the controls were 62.74% and 53.45%, respectively. The gene frequencies of C were 37.26% and 46.55%, respectively. The distribution of allele and genotype frequencies of FGFR2 rs 1219648 was statistically different between breast cancer cases and the controls ( P<0.05). Conclusion:FGFR 2 rs 1219648 polymorphism influences the susceptibility of breast cancer. TT genotype might serve as a risk factor for breast cancer.