Abstract: Objective: To study the clinicopathologic characteristics and the prognostic factors of triple negative breast cancer, and to study the correlation between clinicopathologic features and EGFR expres-sion.Methods:Clinical characteristics and prognosis of 200 breast cancer patients diagnosed between1997 and 2004 were reviewed. The paraffin embedded tissues were selected and tissue microarray blocks were made. Immunohistochemical staining was used to evaluate the expression of ER, PR and HER2 for breast cancer molecular type. EGFR expression was evaluated to analyze its correlation with the clinical characteris -tics and prognosis. Results: Fourty-two cases (21%) of200 were triple negative breast cancer (TNBC). There was no significant difference between TNBC and non-TNBC in clinicopathologic parameters such as age, tu-mor size, clinical stage, and lymph node status. However, there was significant difference in histological cate-gory and menostasis status between the two groups ( P<0.05). Among TNBC, 17of 42died during the fol-low-up (the overall suivival rate was 59.52% ), while26of 158 non-TNBC died (the overall survival rate was 83.54% ). EGFR was significantly overexpressed in TNBC (69.05% ) and it was associated with lymph node status and histological category. Conclusion:Although the incidence of TNBC is low, it has a poorer prognosis than other subtypes. EGFR is highly expressed in TNBC and may serve as a prognostic index and an impor -tant therapatic target for breast cancer.