Abstract: Objective:To investigate the clinical features and survival factors of primary fallopian tube car -cinoma. Methods:We used Kaplan-Meier survival analysis, single factor analysis and multivariate analysis to evaluate the prognostic factors of 40patients diagnosed with primary fallopian tube cancer. Results: The aver -age age of the patients was 51years and all of them received surgery. There were 29(72.5%) stageⅠor Ⅱ patients, 11stage Ⅲor Ⅳpatients. Thirty-one (77.5%) patients were diagnosed with poorly differentiated tu-mors and22(55%) patients had serous adenocarcinoma. Thirty-seven patients received PAC/PC or TC che-motherapy after surgery. Six patients (15%) had recurrences within 23to 56months after surgery. The medi-an survival ofⅠ~ Ⅱand Ⅲ~ Ⅳstage patients was 79and 35months, respectively. The total 5-year survival was 58% and 0 (P=0.005 ). Univariate and multivariate analysis showed that stage ( Ⅰ~ Ⅱvs. Ⅲ~ Ⅳ), grade (G1 +G2 vs. G3), residual disease after surgery (none, <1cm vs. > 1cm) were significant factors affecting surviv-al. In accordance with the formula to calculate the half-life of CA 125 and compare preoperative serum CA125 with the value at 3 weeks after surgery (T1/2>3 week, T1/2<3 week), the 5-year survival was 78% and 50%, re-spectively (P=0.036 ). Conclusion:Special attention should be paid to the joint screening of primary fallopian tube cancer in clinical practice in order to avoid misdiagnosis. The consecutive measurements of serum CA-125 level may have significant value as a prognostic indicator for patient survival.