Abstract:
Objective:To evaluate the efficacy and the adverse reactoions of cetuximab combined with cheomotherapy (oxapliplatin or iriticon) for metastastic colorectal cancer. Methods:A total of22patients with metastastic colorectal cancer were treated with cetuximab combined with FOLFIRI or mFOLFOX6. The patients received cetuximab at an initial dose of 400 mg/m2 intravenously on day 1 in the first cycle, followed by weekly infusion of 250 mg/m2; FOLFIRI: irinotecan 180 mg/m2 on day1, CF 400 mg/m2, 5-FU bolus 400 mg/m2, 5-FU infusion 2400mg/m2 over 46hours, once every 2 weeks; mFOLF -OX6: oxaliplatin 85mg/m2 on day1, CF 400 mg/m2 , 5-FU bolus 400 mg/m2, 5-FU infusion 2400mg/m2 over 46hours, once every 2 weeks. The immediate response, complete response and partial response and changes in tumor marker levels were observed. Results: There were12PR cases, 6 SD cases, and no CR cases. The rate of (CR+PR) was 57.1% and the rate of (CR+PR+SD) was 85.7%. The adverse reactions during the theraphy were skin toxicity and neutropenia. Conclusion:Safe and effective for metastastic colorectal cancer, cituximab combined with oxaliplatin or irinotecan can increase the resectabiliy rate and prolong patient survival.