裴 炜, 梁建伟, 周志祥, 张海增, 邵永孚, 赵 平. 高龄梗阻性结直肠癌的外科治疗[J]. 中国肿瘤临床, 2010, 37(5): 254-256. DOI: 10.3969/j.issn.1000-8179.2010.05.004
引用本文: 裴 炜, 梁建伟, 周志祥, 张海增, 邵永孚, 赵 平. 高龄梗阻性结直肠癌的外科治疗[J]. 中国肿瘤临床, 2010, 37(5): 254-256. DOI: 10.3969/j.issn.1000-8179.2010.05.004
PEI Wei, LIANG Jianwei, ZHOU Zhixiang, ZHANG Haizeng, SHAO Yongfu, ZHAO Ping. Surgical Treatment for Colorectal Cancer with Obstruction in Elderly Patients[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2010, 37(5): 254-256. DOI: 10.3969/j.issn.1000-8179.2010.05.004
Citation: PEI Wei, LIANG Jianwei, ZHOU Zhixiang, ZHANG Haizeng, SHAO Yongfu, ZHAO Ping. Surgical Treatment for Colorectal Cancer with Obstruction in Elderly Patients[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2010, 37(5): 254-256. DOI: 10.3969/j.issn.1000-8179.2010.05.004

高龄梗阻性结直肠癌的外科治疗

Surgical Treatment for Colorectal Cancer with Obstruction in Elderly Patients

  • 摘要: 目的:探讨影响70岁以上高龄结直肠癌伴肠梗阻患者的外科治疗及预后因素。方法:回顾性分析中国医学科学院肿瘤医院腹部外科1992年1 月至2001年12月间收治的31例70岁以上高龄梗阻性结直肠癌患者的临床病理资料。采用Kaplan-Meier 法进行生存分析,Log-rank 检验进行统计学比较;应用Cox 比例风险模型进行多因素分析,对外科治疗及影响预后的因素进行分析。结果:全组患者中位年龄74岁,手术后并发症者7 例(22.6%),手术后30天内死亡2 例(6.5%)。 病理类型分别为管状腺癌28例(高分化5 例,中分化16例,低分化7 例),黏液腺癌3 例。肿瘤Dukes分期B 期8 例,C 期9 例,D 期14例。全组5 年生存率为22.7% 。行根治性手术组的5 年生存率为44.4% ,非根治手术组的5 年的总体生存率为7.7% 。全组的中位生存期为12个月,根治性手术组的中位生存期38个月,非根治组的中位生存期9 个月。单因素分析显示:高龄、合并症、术前CEA 、术前低蛋白血症、手术时间、根治性手术、分期与预后相关。多因素分析表明高龄、术前低蛋白血症为影响老年梗阻性结直肠癌预后的独立因素。结论:高龄梗阻性结直肠癌患者行根治性切除术预后较好,年龄、术前低蛋白血症是影响其预后的独立因素。

     

    Abstract: Objective: To evaluate the surgical procedures and prognostic factors for colorectal carcinoma in patients aged over 70. Methods:We retrospectively reviewed 31colorectal cancer patients aged over 70seen in our hospital be-tween January 1992 and December 2001. Treatment procedures and outcome of these patients were analyzed. Ka -plan-Meier method was used for survival analysis and Cox regression analysis was conducted to analyze prognostic fac-tors. Results: The median age of these patients was74years. The median follow-up period was 12months. The postopera-tive complication rate was 22.6% . The thirty-days mortality was 6.5% . There were 28cases of tubular adenocarcinoma (well differentiated in 5 cases, moderately differentiated in 16cases, and poorly differentiated in 7 cases) and 3 cases of mucinous adenocarcinoma. As to Dukes stage, there were8 cases of B stage, 9 cases of C stge, and 14cases of D stage. The overall5-year survival rate was 22.7%. The5-year survival rate was 44.4% in the radical surgery group and 7.7% in the palliative surgery group. The median survival period of all patients was 12months. The median survival period was38 months in the radical surgery group and 9 months in the palliative surgery group. Univariate analysis showed that the pre-dictors for survival were age, co-morbidity, preoperative serum CEA level, preoperative serum albumin concentration, dura-tion of surgery, radical surgery, and cancer stage. Conclusion:Radical resection is a prerequisite for cure of colorectal can-cer with obstruction in elderly patients. Age and preoperative serum albumin concentration are independent prognostic indi-cators.

     

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