Abstract: Objective: To study the clinical efficacy of Jianpijiangniling combined with chemotherapy for advanced non-small-cell lung cancer (NSCLC). Methods:A total of129 patients were randomly assigned to the treatment group and the control group. All patients received four cycles of chemotherapy. Patients in the treatment group received concurrent four-cycle Jianpijiangniling therapy. Clinical curative effect, overall survival, quality of life, body weight, and side effects were analyzed. Results: No significant difference was found in the total efficiency between the two groups. Patients’quality of life and body weight in the treatment group were superior to those in the control group (P<0.05, P<0.01). Nausea and vomiting were more frequently seen in the control group than in the treatment group ( P<0.05). No statistically significance was found in the rates of diarrhea, constipation, and other adverse effects between the two groups. Marrow suppression was frequently seen in the control group. The rates of leucopenia and decrease in hemoglobin were higher in the control group (P<0.05). The difference in the rate of thrombocytopenia between the two groups was not significant. Conclusion: Jianpijiangniling combined with chemotherapy is effective for advanced non-small-cell lung cancer, with fewer side effects.