Abstract: Objective:To explore the turnover and treament of postoperative remainder of giant nonfunctioning pituitary adenoma with suprasellar extension (SSE). Methods:The clinical data of 68cases suffering from giant nonfunctioning pitu-itary adenoma with suprasellar extension (SSE) admitted into our department were retrospectively analyzed. These pa -tients underwent primary transsphenoidal surgery. Results: Twenty cases had SSE adenomas totally removed (20.6%). In other 48cases (79.34%), SSE residues were shown in MRI recheck at one day after surgery. After3 months, the3rd MRI scanning was performed only to find that tumor residues descended to sellar floor in 21cases, into intrasella in 8 cases, and down to the level of stalk hypophysial and the entrance to the sella in 3 cases. All of patients with residual tumors re -ceived retranssphenoidal resection (the total removal rate of desending SSE residues was 96.9% ). There were2 cases with adenoma residues with slight descending. Obvious SSE adenomas were treated with transtranial approach. The twelve cases with small SSE residues were consecutively observed and two of them received gamma knife treatment be -cause of unobvious postoperative visual improvement. The surgical mortality was0%. There was no death during follow up in all of these patients. There were no cases with rhinorrhea, meningitis or visual deterioration. Two patients had supradia -phragmatic bleeding detected by routine postoperative CT.Conclusion:Staged surgery with two or multiple transsphenoidal resections is an appropriate treatment for giant nonfunctioning pituitary adenoma with suprasellar extension (SSE), with few complications. Futher study is warranted to investigate the growth pattern of pituitary adenoma.