Abstract: Objective: To investigate the clinical and pathological factors related to metachronous liver metastases in patients with Dukes'C colorectal cancer. Methods:A total of 170 patients with Dukes'C colorectal cancer treated with radical surgery in our hospital between January2003 and December 2006 were reviewed. Factors including sex, age, tumor size (cm), depth of invasion, histological type, and serum CEA level were analyzed. Univariate and multivariate analyses were used to evaluate the factors concerned by Binary logistic regression (SPSS 13.0 for windows). Results: Of the 170 cases, 36cases had metachronous liver metastases and 26of them ( 72.2%) were found with metachronous liver metastases with-in two years after surgery. Thirty-two cases (88.9%) were identified with metachronous liver metastases within three years after surgery. Univariate analysis showed that depth of invasion, histological type and serum CEA level were predictors that could affect metachronous liver metastases. Depth of invasion and serum CEA level were independent risk factors for meta chronous liver metastases of colorectal cancer. Multivariate analysis revealed that histological type was independent favor-able factor for metachronous liver metastases of colorectal cancer. Conclusion:Depth of invasion, histological type and se -rum CEA level were independent factors related to metachronous liver metastases of colorectal cancer. It is necessary to closely follow up Dukes'C colorectal cancer patients for two or three years after surgery in order to detect metachronous liv-er metastases early, especially for patients with higher preoperative serum CEA level or with tumor invasion to serosa.