Abstract:
Objective: To evaluate the efficacy and toxicity of rituximab combined with cyclophosphamide, pirarubicin, vincristine, and prednisone (R-CTOP regimen) for B cell non-Hodgkin's lymphoma and to analyze the influential factors for patient response. Methods:The clinical data of patients with CD20antigen treated with R-CTOP regimen were reviewed and the influence of sex, age, clinical stage, pathological type, and level of LDH and IPI on patient response was analyzed. Results:A total of 33patients were evaluated for objective response. The complete response (CR) rate was 51.5%, the par-tical response (PR) rate was 33.3%, and the overall response rate was84.8%. For the 23de novo patients, the CR rate was 56.5 %, the PR rate was 34.8%, and the OR rate was 91.3%. While in the 10recurrent patients, the CR rate was 40%, the PR rate was 30%, and the OR rate was 70%. Sex, clinical stage, pathological type, and the level of LDH and IPI were not significantly related to clinical response. While patient age was related to clinical response. None of the patients died of therapy-related side effects. The most frequent adverse event was myelosuppression ( Ⅲ- Ⅳdecrease of leukocyte account-ed for 32.1%). Cardiotoxicity and alopecia were mostly gradeⅠto grade Ⅱ. Other side effects can be tolerated after symp -tomatic treatment. Conclusion:R-CTOP regimen is a highly effective and well toleraed therapy and should be the first choice in the treatment for B cell non-Hodgkin’s lymphoma (NHL), especially for senior patients.