Abstract: Objective:To investigate prognostic factors of survival of lung adenocarcinoma patients with brain metasta -ses. Methods:The clinical data of 109 lung adenocarcinoma patients with brain metastases were reviewed. Fifty-senven pa -tients survived more than 1 year, and52patients survived less than 1 year. The data were analyzed by SPSS 15.0 statisti -cal software. Results: Both the univariate analysis and multivariate analysis showed that patients' PS score, the interval be -tween diagnosis and brain metastasis, and multimodality treatment were independent prognostic factors for the survival of lung adenocarcinoma patients with brain metastases (P<0.05). Patients' gender, age, metastatic symptoms and extracrani-al metastases didn't significantly affect patient survival. Conclusion:Patients with PS score0-1, the interval of more than 1 year between diagnosis and brain metastasis, and combined therapy have longer survival. The research provides an impor-tant guidance for the treatment of advanced lung adenocarcinoma patients with brain metastases.