The Microvessel Density and Expression of MMP- 2 and MMP- 9 in Hepatocellular Carcinoma and Their Correlation with Metastasis and Prognosis
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摘要: 目的:探讨微血管密度(MVD)、基质金属蛋白酶-2(MMP-2)和MMP-9 在肝细胞肝癌转移中的作用及其各自和预后的相关性。方法:以石蜡包埋组织切片,免疫组化SP法染色分别检测97例肝细胞肝癌MVD和MMP-2、MMP-9 表达的情况,其中复发与转移组49例,非复发与转移组48例。结果:转移组MVD高于无转移组(P=0.015),转移组MMP-2 和MMP-9 表达高于无发转移组(P=0.009,P=0.043),差异具有统计学意义。结论:MVD增高、MMP-2 和MMP-9 过度表达可能与肝细胞肝癌转移、不良生存预后存在相关性。Abstract: Objective:To investigate the effect of microvessel density and expression of MMP- 2 and MMP- 9 on the me-tastasis of hepatocellular carcinoma and their correlation with patients ’prognosis. Methods:Immunohistochemistry (SP) was employed to detect MVD and expression of MMP-2 and MMP- 9 in 97samples of hepatocellular carcinoma. There were 49cases with metastasis and 48cases with no metastasis. Results: The abnormal MVD and expression of MMP-2 and MMP- 9 in cases with metastasis were higher than those in cases with no metastasis (P=0.015 ; P=0.009 ). Conclusion: Abnomal MVD and expression of MMP- 2 and MMP- 9 may play an important role in the metastasis of hepatocellular carci-noma and indicate poor prognosis.
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Key words:
- MVD /
- MMP-2 /
- MMP-9 /
- Metastasis
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